Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Structural basis of efficacy-driven ligand selectivity at GPCRs.

Powers, Alexander S; Pham, Vi; Burger, Wessel A C; Thompson, Geoff; Laloudakis, Yianni; Barnes, Nicholas W; Sexton, Patrick M; Paul, Steven M; Christopoulos, Arthur; Thal, David M; Felder, Christian C; Valant, Celine; Dror, Ron O.

Nat Chem Biol ; 19(7): 805-814, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-36782010

2.

Role of Conserved Tyrosine Lid Residues in the Activation of the M₂ Muscarinic Acetylcholine Receptor.

Pham, Vi; Habben Jansen, Maria Clazina Cornelia; Thompson, Geoff; Heitman, Laura H; Christopoulos, Arthur; Thal, David M; Valant, Celine.

Mol Pharmacol ; 104(3): 92-104, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37348914

3.

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

Brouwer, Jason M; Westphal, Dana; Dewson, Grant; Robin, Adeline Y; Uren, Rachel T; Bartolo, Ray; Thompson, Geoff V; Colman, Peter M; Kluck, Ruth M; Czabotar, Peter E.

Mol Cell ; 55(6): 938-946, 2014 Sep 18.

Artigo em Inglês | MEDLINE | ID: mdl-25175025

4.

Crystal structure of the M₅ muscarinic acetylcholine receptor.

Vuckovic, Ziva; Gentry, Patrick R; Berizzi, Alice E; Hirata, Kunio; Varghese, Swapna; Thompson, Geoff; van der Westhuizen, Emma T; Burger, Wessel A C; Rahmani, Raphaël; Valant, Celine; Langmead, Christopher J; Lindsley, Craig W; Baell, Jonathan B; Tobin, Andrew B; Sexton, Patrick M; Christopoulos, Arthur; Thal, David M.

Proc Natl Acad Sci U S A ; 116(51): 26001-26007, 2019 12 17.

Artigo em Inglês | MEDLINE | ID: mdl-31772027

5.

Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.

Powers, Alexander S; Pham, Vi; Burger, Wessel A C; Thompson, Geoff; Laloudakis, Yianni; Barnes, Nicholas W; Sexton, Patrick M; Paul, Steven M; Christopoulos, Arthur; Thal, David M; Felder, Christian C; Valant, Celine; Dror, Ron O.

Nat Chem Biol ; 19(4): 529, 2023 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-36879062

6.

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.

Yao, Shenggen; Westphal, Dana; Babon, Jeffrey J; Thompson, Geoff V; Robin, Adeline Y; Adams, Jerry M; Colman, Peter M; Czabotar, Peter E.

Arch Biochem Biophys ; 545: 33-43, 2014 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-24434006

7.

The importance of an external clinical audit.

Thompson, Geoff.

Br J Community Nurs ; 23(Sup9): S40-S41, 2018 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-30156879

8.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Vuckovic, Ziva; Wang, Jinan; Pham, Vi; Mobbs, Jesse I; Belousoff, Matthew J; Bhattarai, Apurba; Burger, Wessel A C; Thompson, Geoff; Yeasmin, Mahmuda; Nawaratne, Vindhya; Leach, Katie; van der Westhuizen, Emma T; Khajehali, Elham; Liang, Yi-Lynn; Glukhova, Alisa; Wootten, Denise; Lindsley, Craig W; Tobin, Andrew; Sexton, Patrick; Danev, Radostin; Valant, Celine; Miao, Yinglong; Christopoulos, Arthur; Thal, David M.

Elife ; 122023 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-37248726

9.

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

Czabotar, Peter E; Lee, Erinna F; Thompson, Geoff V; Wardak, Ahmad Z; Fairlie, W Douglas; Colman, Peter M.

J Biol Chem ; 286(9): 7123-31, 2011 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-21199865

10.

The health of Indigenous Australians.

Thompson, Geoff; Talley, Nicholas J; Kong, Kelvin M.

Med J Aust ; 207(1): 19-20, 2017 07 03.

Artigo em Inglês | MEDLINE | ID: mdl-28659107

11.

Biased Profile of Xanomeline at the Recombinant Human M₄ Muscarinic Acetylcholine Receptor.

McDonald, Jack K; van der Westhuizen, Emma T; Pham, Vi; Thompson, Geoff; Felder, Christian C; Paul, Steven M; Thal, David M; Christopoulos, Arthur; Valant, Celine.

ACS Chem Neurosci ; 13(8): 1206-1218, 2022 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-35380782

12.

Identification of a Novel Allosteric Site at the M₅ Muscarinic Acetylcholine Receptor.

Burger, Wessel A C; Gentry, Patrick R; Berizzi, Alice E; Vuckovic, Ziva; van der Westhuizen, Emma T; Thompson, Geoff; Yeasmin, Mahmuda; Lindsley, Craig W; Sexton, Patrick M; Langmead, Christopher J; Tobin, Andrew B; Christopoulos, Arthur; Valant, Celine; Thal, David M.

ACS Chem Neurosci ; 12(16): 3112-3123, 2021 08 18.

Artigo em Inglês | MEDLINE | ID: mdl-34351123

13.

Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model.

Kamili, Saleem; Sozzi, Vitini; Thompson, Geoff; Campbell, Katie; Walker, Christopher M; Locarnini, Stephen; Krawczynski, Krzysztof.

Hepatology ; 49(5): 1483-91, 2009 May.

Artigo em Inglês | MEDLINE | ID: mdl-19274751

14.

Field Evaluation of Deltamethrin and Ivermectin Applications to Cattle on Culicoides Host-Alighting, Blood-Feeding, and Emergence.

Murchie, Archie K; Thompson, Geoff M; Clawson, Sam; Brown, Andrew; Gordon, Alan W; Jess, Stephen.

Viruses ; 11(8)2019 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-31398840

15.

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.

Hollingsworth, Scott A; Kelly, Brendan; Valant, Celine; Michaelis, Jordan Arthur; Mastromihalis, Olivia; Thompson, Geoff; Venkatakrishnan, A J; Hertig, Samuel; Scammells, Peter J; Sexton, Patrick M; Felder, Christian C; Christopoulos, Arthur; Dror, Ron O.

Nat Commun ; 10(1): 3289, 2019 07 23.

Artigo em Inglês | MEDLINE | ID: mdl-31337749

16.

Percutaneous parathyroid ethanol ablation in patients with multiple endocrine neoplasia type 1.

Veldman, Mark W; Reading, Carl C; Farrell, Michael A; Mullan, Brian P; Wermers, Robert A; Grant, Clive S; Thompson, Geoff B.

AJR Am J Roentgenol ; 191(6): 1740-4, 2008 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-19020245

17.

An overview of negative pressure wound therapy (NPWT).

Thompson, Geoff.

Br J Community Nurs ; 13(6): S23-4, S26, S28-30, 2008 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-18773763

18.

An overview of wound healing and exudate management.

Thompson, Geoff; Stephen-Haynes, Jackie.

Br J Community Nurs ; 12(12): S22, S24-6, S28-30, 2007 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18361171

19.

Softform Premier Active mattress: a novel step-up/step-down approach.

Thompson, Geoff.

Br J Nurs ; 15(18): 988-93, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-17077769

20.

Acrylamide: update on selected research activities conducted by the European food and drink industry.

Taeymans, Dominique; Andersson, Anders; Ashby, Peter; Blank, Imre; Gondé, Pierre; van Eijck, Paul; Faivre, Virginie; Lalljie, Sam P D; Lingnert, Hans; Lindblom, Marianne; Matissek, Reinhard; Müller, Detflef; Stadler, Richard H; Studer, Alfred; Silvani, David; Tallmadge, Dan; Thompson, Geoff; Whitmore, Tricia; Wood, John; Zyzak, David.

J AOAC Int ; 88(1): 234-41, 2005.

Artigo em Inglês | MEDLINE | ID: mdl-15759746

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Structural basis of efficacy-driven ligand selectivity at GPCRs.

Role of Conserved Tyrosine Lid Residues in the Activation of the M₂ Muscarinic Acetylcholine Receptor.

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

Crystal structure of the M₅ muscarinic acetylcholine receptor.

Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.

The importance of an external clinical audit.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

The health of Indigenous Australians.

Biased Profile of Xanomeline at the Recombinant Human M₄ Muscarinic Acetylcholine Receptor.

Identification of a Novel Allosteric Site at the M₅ Muscarinic Acetylcholine Receptor.

Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model.

Field Evaluation of Deltamethrin and Ivermectin Applications to Cattle on Culicoides Host-Alighting, Blood-Feeding, and Emergence.

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.

Percutaneous parathyroid ethanol ablation in patients with multiple endocrine neoplasia type 1.

An overview of negative pressure wound therapy (NPWT).

An overview of wound healing and exudate management.

Softform Premier Active mattress: a novel step-up/step-down approach.

Acrylamide: update on selected research activities conducted by the European food and drink industry.